The interaction between antigenic peptides and MHC molecules Zhejiang Hongtuo Biotechnology Co., Ltd. is a company dedicated to providing customers with professional, high-quality and high-efficiency biomedical technology services. It is headquartered in the beautiful Hangzhou Haichuang Park. The planned area of ​​Haichuang Park is 113 square kilometers. It is located on the west side of Hangzhou city center, adjacent to Xixi National Wetland Park and Zhejiang University. It has superior location, beautiful environment, abundant resources and vast space. It is the key city of Hangzhou City during the 12th Five-Year Plan period. Create an innovative nuclear core in the industrial cluster. The company has a total area of ​​more than 2,000 square meters and has 7 laboratories. Adhering to the concept of “people-oriented, pursuing excellenceâ€, the company has established a technical service team with first-class bio-elite talents to create a top-level biomedical technology service platform. Dustproof lighting fitting,dust proof fluorescent fitting,Double Fluorescent Fitting Ningbo Wellway Optoelectronic Technology Co.,Ltd , https://www.wellwayopto.com
A particular MHC molecule can selectively bind an antigenic peptide by virtue of the desired shared motif , in the sense that the combination of the two has a certain degree of specificity. It is thus inferred that different MHC allelic products may present different epitopes of the same antigen molecule, resulting in differences in the intensity of response of the same antigen to different individuals (with mutually different MHC alleles). This is actually an important mechanism by which MHC participates in and regulates immune responses with its polymorphism.
In-depth study found that, recognition of MHC molecules presenting antigenic peptides is not a strict one relationship, but a type of MHC molecules can be identified with a specific group of peptides common motif, which constitutes the MHC molecules with antigenic peptides each other The flexibility of the role. This inclusiveness can be expressed at different levels: first, the amino acid represented by 'x' in the common motif can be changed in order and structure; secondly, the same MHC molecule (especially the class II molecule) is required to be extracted into peptides. Anchoring residues often have more than one amino acid. As a result, the number of peptides that conform to a common motif can be quite large, resulting in the possibility that one MHC molecule can bind multiple antigenic peptides and activate multiple antigen-specific T cell clones; Finally, antigenic peptides received by different MHC molecules can also share the same common motif. For example, at least four families of A2, A3, B4, and B44 have been identified in HLA class I molecules, and members of these families can selectively recognize antigenic peptides possessing the same or similar anchor residues. This means that antigenic peptides that can be recognized and presented by a certain HLA molecule can also be presented by other molecules of the family. Http:// This facilitates the use of peptide vaccines or T-cell vaccines for immunoprophylaxis and immunotherapy.