Release date: 2018-04-24 Image source: Pixabay Osteoarthritis (OA) is a common complication of obesity. The past view is that obese people have osteoarthritis associated with excessive joint stress. However, researchers at the University of Rochester Medical Center have confirmed for the first time in this latest study that dietaryly regulated gut flora may be the main driver of osteoarthritis. Michael Zuscik, associate professor of the Musculoskeletal Research Center (CMSR), Robert Mooney, professor of pathology medicine, and Steven Gill, associate professor of microbiology and immunology, found that obese mice had more harmful bacteria in their bodies than slender mice. These bacteria cause systemic inflammation, which causes the joints to deteriorate rapidly. Doi:10.1172/jci.insight.95997 High fat diet The research team fed mice with high-fat foods (similar to “cheese burgers + milkshakesâ€). After 12 weeks, the high-fat diet caused nearly double the amount of fat in the mice, which in turn led to problems such as obesity and diabetes. . At the same time, the mouse colon is controlled by pro-inflammatory bacteria, almost completely lacking certain beneficial strains. Changes in the intestinal flora of mice are consistent with signs of systemic inflammation, including osteoarthritis. Compared with lean mice, obese mice have faster bone and joint damage, and almost all cartilage disappears within 12 weeks due to wear and tear. “Cartilage is a cushioning and lubricant that supports frictionless joint movement,†says Michael Zuscik. “Once the cartilage is worn out, the bones and bones will rub directly, causing joint pain and greater damage.†Improve inflammation and protect bones and joints Surprisingly, when a high-fat diet group was supplemented with a common probiotic oligofructose, the effects of obesity on intestinal bacteria, inflammation, and osteoarthritis were completely avoided. There is no significant difference between the knee cartilage of this type of mouse and the cartilage tissue of normal mice. Although probiotics are not digested by rodents or humans, they are popular with certain beneficial gut flora (eg, bifidobacteria). Once the beneficial bacteria are grown with active nutritional supplements, there is an opportunity to “kill†harmful bacteria, such as pro-inflammatory bacteria. This positive change will further reduce the risk of inflammation and slow the damage of articular cartilage in mice. Probiotic supplements can reduce the risk of developing diabetes in mice, but they do not reduce weight. That is to say, even with the addition of probiotics, high-fat mice are overweight, and their joints still bear the same load, but they are healthier than before. This result supports a new view that reducing inflammation alone is enough to protect articular cartilage tissue, which is the main driver of osteoarthritis and joint degeneration. "This further proves that osteoarthritis is a complication of obesity, similar to diabetes, heart disease and stroke, partly due to inflammation," Robert Mooney said. Clinical trials have yet to be verified The researchers stressed that although the microbiota between mice and humans have similarities, bacteria that protect mice from osteoarthritis caused by obesity may not be directly applicable to humans. They plan to work with the Military and Veteran microbiome team to verify the effectiveness of supplemental probiotics in relieving human osteoarthritis by comparing the differences between veterans (the presence of obesity-associated osteoarthritis) and normal people. “The latest research tells us that although supplementation with probiotics does not help mice lose weight, it completely relieves other symptoms, including improving the intestinal flora and slowing joint pain.†The first author of the article, Dr. Eric Schott, said, “We have not slowed down before. The method of arthritis, and there is no way to reverse the damage that has been caused. Now, this research lays the foundation for the treatment of targeted microbiota." Reference materials: The bugs in your gut could make you weak in the knees Source: Bio-Exploration Laryngeal mask airway,lma airway,laryngeal mask,lma 2 MEDS TECHONOLOGY CO.,LTD , https://www.2-meds.com
