Collagen is the most abundant protein in mammals, accounting for 25% to 30% of the total protein. It is widely present in all tissues from the body surface of lower vertebrates to mammalian bodies. Collagen monomers are long cylindrical proteins with a length of about 280 nm and a diameter of 1.4–1.5 nm. It consists of 3 polypeptide chains that are supercoiled around each other. Collagen,Collagen Peptides,Collagen costco,Collagen Peptide Products YT(Xi'an) Biochem Co., Ltd. , https://www.ytlinkherb.com
Rapid solid phase peptide synthesis by controlled microwave heating
Rapid solid-phase peptide synthesis using thermal and controlled microwave irradiation
Abstract: A rapid and efficient microwave-assisted solid-phase synthesis method is described for the preparation of thenonapeptide WDTVRISFK , using conventional Fmoc/Bu t orthogonal protection strategy. The synthesis protocol is based on the use of cycles of pulsed microwave irradiation with intermittent cooling of The reaction during the removal of the Fmoc protection group and during the coupling. The desired nonapeptide was obtained in the highest yield and purity by employing MicroKantechnology . The chemical reactions were carried out in a single-mode microwave reactor, equipped with a fiber-optic probe tomonitor The reaction temperature continuously.
Abstract: This paper describes a fast and efficient microwave-assisted solid phase synthesis method for the synthesis of short peptides of the sequence WDTVRISFK using the traditional Fmoc (9-fluorenyloxycarbonyl)/tBu (tert-butyl) protecting group strategy. The synthesis method is based on periodic pulsed microwave radiation and intermittent cooling in the reaction, and is applied in the removal and coupling reaction of the Fmoc protecting group. The high purity and high yield of the target polypeptide is obtained after the application of the microreactor technology. The reaction was carried out in a CEM single mode microwave reactor and continuous temperature measurement was performed using an optical fiber.
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Rapid solid-phase peptide synthesis using thermal and controlled microwave irradiation