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[China Pharmaceutical Network Technology News] Recently, the State Key Laboratory of Bioreactor Engineering of East China University of Science and Technology, and Professor Wei Dongzhi of Luhua Institute of Biotechnology, obtained a recombinant protein TAT-IL-targeting tumor cells. 24-KDEL, and is expected to develop it as a new anti-tumor drug. 
Recently, the research results were published online on the famous Oncotarget in the field of cancer research.
Interleukin-24 (IL-24) induces apoptosis in a variety of tumor cells, and has little effect on the growth and viability of normal cells. Therefore, it is a promising protein drug. In this study, the recombinant expression of IL-24 was expressed by E. coli expression system and its anti-tumor mechanism was explored. According to the mechanism of action of IL-24, it can be targeted and modified, so that IL-24 can specifically act on tumor cells. The molecular chaperone receptor GRP78 on the endoplasmic reticulum. Experiments have shown that it exhibits good antitumor activity in both in vitro and in vivo experiments. At the same time, this study also found that the anti-tumor activity of IL-24 was largely inhibited in tumor cells with high expression of anti-apoptotic protein survivin, and the sensitivity of tumor cells to IL-24 was observed after survivin gene interference expression. Significantly enhanced, therefore, by combining the small molecule inhibitors of survivin, YM155 and IL-24, the resistance of tumor cells to IL-24 can be reversed.
The work was mainly completed by the post-doctor Zhang Jian, the communication authors were Sun Aiyou and Wei Dongzhi, and received great assistance from Tao Xinyi. The research work of the thesis was completed with the support of Professor Wei Dongzhi's special new drug creation special "biotechnology drug pilot scale amplification and separation and purification technology platform".
New achievements in East China Institute of Technology research will develop new anti-tumor drugs
(Original title: New achievements in Huali research are expected to be developed as new anti-tumor drugs)