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Researcher Lihong Wang said that by genetically modifying glioblastoma cells to express BphP1 protein, we can use photoacoustic tomography to clearly observe hundreds of thousands of tissues at a depth of 1 cm. Living cancer cells, photoacoustic tomography is a new type of non-destructive non-invasive biomedical imaging technology; for the first time in this paper, researchers have deeply invasive techniques, high-resolution photoacoustic imaging technology with reversible variable Switching non-fluorescent bacterial phytochrome was studied in combination.
The researchers point out that the genetic coding of proteins allows us to image and target the biological processes deep in the tissue, while the light-switching properties of proteins can also be used as new imaging functions; BphP1 proteins can sense unwanted types of light. At the same time, the absorption characteristics are changed accordingly. This feature can help researchers use two types of light: red or near-infrared light to obtain imaging results of cancerous tissues, and can also compare imaging results to obtain cancer cells. Highly sensitive and high resolution imaging results.
Using photoacoustic tomography, the researchers first revealed the specific proteins expressed in cancerous tissues with the help of near-infrared light, which changed the absorption characteristics. Then the researchers used red light to irradiate the cancerous tissue. The kinesin switch allows it to return to its original state. When the secondary imaging is subtracted, the blood signal and other unknown imaging backgrounds are eliminated, so that the researchers can more clearly observe the presence of cancer cells and their metastasis.
Researcher Yao pointed out that the new technology developed in this study is very useful for cancer imaging. When we first saw early cancer, there was no difference between cancer tissue and healthy tissue, because rich blood gave it a strong enough signal. The cancer cells are not highlighted, and researchers using this new technology can now observe cancer when it is small.
In the previous study, only relatively advanced cancer cells could be seen in the tissue, because the strong background signal from the blood would block the cancer cells, and the new technology developed by the researchers in this paper can not only help cancer research, but also use In the study of cardiac tissue and cancer immunotherapy, the development of new technologies has provided biologists with a new tool for genetically specific high-resolution and deep imaging studies of cancer, as well as the development of new cancer drugs. .
High-tech imaging methods help cancer cells detect
[China Pharmaceutical Network Technology News] New technology development provides biologists with a new tool for cancer-specific high-resolution and deep imaging research, and will also help the development of new cancer drugs. It is reported that scientists from the University of Washington can use high-tech imaging methods to clearly see early-stage cancer cells in the depths of the tissue, which may be more clear and intuitive than using fluorescent proteins to observe cancer cells.