It was learned from Nankai University that the research group of the National Key Laboratory of Elemental Organic Chemistry, Professor Chen Gong, developed a novel organic chemical reaction method that allowed the three-stage carbon chiral center with non-acid protons to plague the chemical industry for many years. The configuration flips to achieve high efficiency and controllability. As an important advance in the field of free radical chemistry, this work provides a convenient and efficient "configuration flip" tool for structural modification and organic synthesis of drug molecules. A few days ago, related papers were published in the American Chemical Society. Changes in the chemical structure of the drug molecule directly lead to changes in drug function. Chemists have successfully developed a variety of synthetic methods to stereostructure various molecular structures. "Currently the 'differential phase isomerization' method is limited to carbon atoms with higher acid protons, and the regulation of the more common carbon atoms with non-activated carbon-hydrogen bonds is at a loss." Chen Gong introduced. Inspired by biosynthesis in nature, Chen Gong's group designed a novel free radical reaction strategy to reversibly cut off and reconstruct inert carbon-hydrogen bonds on specific tertiary carbon atoms to achieve their stereochemical reversal. "Chemical synthesis of complex molecules is like building Lego toys. Even if there is a carbon atom in the synthesis of natural products or drug molecules containing many atoms, the stereochemistry will bring fatal deviation." Chen Gong introduced these three-dimensional Deviations in chemical regulation often constitute "roadblocks" in organic synthesis routes. In order to correct these subtle deviations, researchers often need to make long rounds of detours to reach "outside the wall" destinations. "Our stereochemistry flipping method can be said to provide synthetic chemists with a 'breaking wall tool'. In some specific cases, the stereochemical deviation can be corrected in situ, so that there is no need to go around." Chen Gong said. This novel organic synthesis method uses a "high valence iodine" reagent to achieve efficient configuration flipping of various cyclic alkane compounds under very mild, simple reaction conditions. Related mechanism studies have revealed that azide radicals can act as a hydrogen atom acceptor to transport hydrogen atoms back and forth between tertiary carbon atoms. Currently, this synthetic method has been successfully applied to the structural inversion of steroid compounds. The exchange of hydrogen atoms in the compound with its isotope æ°˜ atoms can be achieved, providing a new path for the preparation of isotope-labeled molecules that are widely used in biomedicine. (Reporter Li Zhe correspondent Wu Junhui)
Gaffer tape introduction
1. Material
Our gaffer tape is based on premium grade cloth fabric, combined with matt polyethylene, coated with synthetic rubber adhesive or natural rubber adhesive.
2. Features
Our Gaffer tape has following features:
a. Strong adhesion, we coated with high quality imported glue.
b. Heavy duty, it is made from strong material, thickness reaches 250micron, 270micron and 300micron.
c. Matt surface, non reflective.
d. No residue when removal.
e. Different colors for choosing. We have black, orange, pink, apple green, other colors also can be customized.
Gaffer Tape,Cloth Gaffer tape,Gaffers Tape,Gaff Tape,Black Gaffer tape,Gaffer duct tape Kunshan Jieyudeng Intelligent Technology Co., Ltd. , https://www.yuhuanptapes.com