Challenge the routine! The higher the "good cholesterol", the better. August 16, 2016 Source: Bio Valley Human total cholesterol refers to the total cholesterol content in human blood, including proteins such as very low density lipoprotein (VLDL), low density lipoprotein (LDL), intermediate density lipoprotein (IDL) and high density lipoprotein (HDL). Cholesterol, in which cholesterol is bound to HDL, is called HDL cholesterol (HDL-C). HDL-C is often touted as a "good cholesterol" that helps reduce the risk of stroke and heart attack. Cholesterol bound to low density lipoprotein is called low density lipoprotein cholesterol (LDL-C). LDL-C is considered to be "bad cholesterol" because it causes plaque formation that can block arteries, making arterial flexibility worse.
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In a new large-scale epidemiological study, researchers from the St. Louis School of Medicine and the Veterans Affairs St. Louis Health Care System at the University of Washington found high and low levels of HDL- C may increase the risk of a person dying prematurely. Conversely, intermediate levels of HDL-C may increase lifespan. Related research results were published online August 10, 2016 in the journal Journal of the American Society of Nephrology , entitled "High Density Lipoprotein Cholesterol and the Risk of All-Cause Mortality among US Veterans."
Dr. Ziyad Al-Aly, author of the paper and author of the University of Washington Medical Assistant, said, "These findings surprised us. People thought that good cholesterol levels were good. The level of increased HDL-C and earlier death exists. Relevance is unexpected and has not been fully understood so far. This will require further research."
Cholesterol is a fatty substance found in the blood that narrows blood vessels and blocks blood vessels, leading to cardiovascular disease and stroke . For many years, HDL-C has been hailed as a "bad cholesterol" that helps remove plaque from the arteries.
In this study, researchers studied kidney function and HDL-C levels in more than 1.7 male veterans from October 2003 to September 2004. Since then, the researchers have followed up on these veterans until September 2013.
Patients with kidney disease often have lower levels of HDL-C, which may explain their increased risk of early death; however, among these patients, the association between increased levels of HDL-C and premature death has been It is not clear. In the current study, the researchers found that high levels of HDL-C and low levels of HDL-C were associated with increased risk of death among patients with various renal functions participating in the study.
Al-Al said, "These findings may explain that clinical trials aimed at increasing HDL-C levels do not improve clinical outcomes."
Al-Aly said that these findings about HDL-C and premature death have not been reported in other large epidemiological studies that speed up understanding of the relationship between cholesterol parameters and clinical outcomes.
“However, previous studies have always had limitations, because the number of patients is relatively small in these cohort studies, and in our new study, we used one,†he said. A big data approach to analysis. Big data allows for a more nuanced study of the relationship between HDL-C and mortality risk across the entire HDL-C level."
According to Al-Aly, “There is a U-shaped curve between HDL-C levels and mortality. At both ends of the curve, the risk of death increases. Too low and too high levels of HDL-C and higher The risk of death is linked."
Al-Aly said that maintaining intermediate levels of HDL-C is likely to increase life expectancy will require further exploration in future research.