Release date: 2017-07-17 Researchers from the Brigham and Women's Hospital (BWH) and the Harvard Stem Cell Institute have found a potential solution to eliminate cancer cells that have metastasized to the brain. The team developed anti-cancer viruses that provide stem cells for the carotid arteries and apply them to mice that have metastases to the brain. The researchers pointed out in the research report that this method can eliminate brain metastasis of skin cancer. Source: Noble Foam Dressing,Soft Elastic Waterproof Foam Dressing,Breathable Foam Dressing,High Absorbency Trauma Foam Dressing Zhende Medical Co.,Ltd , https://www.zhendemedicals.com
The full study was published in the online journal PNAS, which also describes a strategy-point inhibitor that combines this therapy with an immunoassay.
The study said: "Migative brain tumors are usually the most common feature of lung cancer, breast cancer or skin cancer. Among them, the proportion of melanoma brain metastases reaches 40%. Currently, there are limited options for treating such patients, especially after metastasis. Our research targets multiple brain metastatic oncolytic viruses that specifically kill and divide tumor cells."
In this trial, the researchers developed a potential new treatment. First, they made human bone marrow mesenchymal stem cells, which are rich in oncolytic herpes simplex virus (oHSV), specifically kill cancer cells while retaining Normal cells. Previous studies have shown that different stem cell types naturally attract tumors in the brain, and after validation, the researchers injected stem cells into the brain to travel to multiple metastatic sites and different tumor fields. The results of the study are exciting.
The researchers said: "We are developing other cancer animals like brain metastases, as well as new oncolytic viruses that can kill multiple drug-resistant tumor cells. We hope that our findings will overcome the current clinical process of the problem, In the clinic, direct use of oncolytic virus to eliminate brain metastatic cancer cells."