New biomarker detection methods can help identify multiple diseases

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Release date: 2018-02-13

Recently, scientists have found a new way to identify a range of diseases through biomarkers. A specific way is to detect antibodies produced by the body that target complex polysaccharides on the surface of autologous cells.

This highly sensitive detection method can detect the level of antibodies produced by the body that target these polysaccharides, thereby contributing to the diagnosis and treatment of cancer, autoimmune diseases and dementia. The results are published in the most recent issue of Nature Communications.

(Source: Phil Jones, Senior Photographer, Augusta University)

The sugars that coat the cell surface have a major effect on the health of the cells as well as the body. It helps cells find other cells that bind, as well as protect against infection by viruses and bacteria. However, such protective layers may become targets of the body's immune system in some cases, and this misidentification and killing will have a significant impact on the function of the cells, leading to disease.

Similar to cells, the bead surface developed by scientists in this test method is also coated with similar beads, which can detect the type and level of antibodies in the human blood that target the above-mentioned sugars, thereby contributing to the disease. Diagnosis.

In fact, the authors have begun to use this technique to identify potential biomarkers for ovarian cancer patients who have relapsed after conventional chemotherapy. "Although we believe that this test can be applied to a variety of clinical practices, we now have evidence to support its ability to identify biomarkers for recurrent cancer." The authors of the study said.

The authors believe that this broad-spectrum, high-throughput detection of polysaccharide antibodies will become a routine test in the future, just as blood lipids are detected in the same way as cholesterol, providing more information for the diagnosis of the disease.

Information source: New technology enables identification of biomarkers for a wide range of diseases

Original source: Sharad Purohit et al. Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins, Nature Communications (2018). DOI: 10.1038/s41467-017-02747-y

Source: Bio Valley

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