Chinese scientists transform gastric cells into liver and pancreatic cells for the first time July 27, 2016 Source: Medical Valley The Academy of Military Medical Sciences of the People's Liberation Army has made another major breakthrough in the field of stem cell research. The reporter learned from the Institute of Field Blood Transfusion on the 22nd that the team led by the researcher Wang Yifang and researcher Qi Xuetao made a revolutionary research result - they used small molecule compound technology to successfully transform human gastric epithelial cells into multiple potentials. Endoderm progenitor cells, which can be induced to differentiate into mature hepatocytes, pancreatic cells and intestinal epithelial cells, etc., will bring new hope for the future treatment of end-stage liver disease and diabetes with stem cell technology. The internationally renowned academic journal Cell-Stem Cell published this important achievement online on the afternoon of the 21st. The three doctors of Jin Jinhua, Wang Shuyong and Zhang Wencheng are the co-first authors of the paper. Previously, the Liu Bing team of the hospital had just published a heavy paper on the origin of hematopoietic stem cells in Nature. According to experts, this study breaks through the dependence of classical reprogramming on transcription factors and enriches the theoretical system of stem cell regeneration biology. It has for the first time in the world to use small molecule compounds to induce the direct conversion of human gastric epithelial cells into endoderm progenitor cells. It provides a safe, controllable and effective source of seed cells for functional cells derived from endodermal cells such as mature hepatocytes and pancreatic cells. It has broad application prospects in personalized regenerative medicine treatment, drug screening and disease model construction. Using this technical principle, humans are expected to achieve the fate conversion of other tissue cells, and their specific types of disease treatment and wound tissue repair regeneration. It is understood that there are many methods for inducing somatic cell reprogramming, such as nuclear transfer, gene induction and chemical induction. At present, it mainly refers to two processes: first, the process of reversing the differentiated cells back to the pluripotent state; second, from A process in which differentiated cells are transformed into another differentiated cell. In 2007, British scientist John Gordon and Japanese scientist Yamanaka Yamanaka discovered through long-term research that skin cells can be induced into pluripotent stem cells and then transformed into heart, nerve and other somatic cells, breaking the previous belief that cell fate is "unchangeable." "This limitation of understanding. Because it circumvents the ethical constraints of using human embryos to extract stem cells and has individual-specific advantages, this research has been rapidly and widely used around the world, which has greatly helped to study diseases that are beyond the reach of traditional methods. Received the 2012 Nobel Prize in Biology or Medicine. Pain Relief Patch For Neck Shoulder,Lower Back And Leg
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