Prof. Ailong Ke from the Department of Molecular Biology and Genetics at Cornell University is mainly engaged in the research of CRISPR, RNA biology, RNA molecular structure and function, structural biology, etc. The research results in the field of nucleic acid switches are at the top level in the world. Recently, the research team collaborated with the Maofu Liao research group of Harvard Medical School to publish the near-atom resolution structure of the type I CRISPR complex of Thermobifida fusca, and revealed the role of the CRISPR-Cas3 system. mechanism. The research was published in the June 29 issue of Cell. Professor Ailong Ke Professor Maofu Liao The breakthrough in this research is: The new study obtained structural images of near-atom resolution, and analyzed how the CRISPR search for target DNA and prepare key steps for DNA that can be used for Cas3 enzymatic cleavage; The results reveal a multi-layered error detection mechanism that prevents accidental genomic damage from occurring; This study provides a structural understanding of improving the accuracy of genetic editing in the CRISPR system, which will help reduce off-target effects. CRISPR-Cas3 System Infusion set,injection products,iv set,iv infusion set,i.v cannula 2 MEDS TECHONOLOGY CO.,LTD , https://www.2-meds.com
