Release date: 2017-04-06 "Chromosomal aneuploidy" is the main cause of infertility, abortion, embryonic cessation and fetal defects in humans. Why is there an aneuploidy? Researchers from all over the world have presented various explanations for many years, but have not revealed the root cause of the problem. Recently, the team of Professor Zhang Liangran from Shandong University and the team of academicians of Harvard University Nancy Kleckner have made a breakthrough explanation for this question for the first time. The results were published in the recently published World Life Sciences authoritative journal Cell (Cell). It is understood that chromosome aneuploidy is a genetic imbalance caused by the loss or increase of one or more chromosomes. In non-cancerous diseases, the most common aneuploidy is Down's syndrome (congenital disorder). The child acquired three chromosomes 21 due to heredity, rather than the normal two. In this way, redundant genetic information leads to dysplasia and nervous system abnormalities in the child. Zhang Liangran told Science Daily that the probability of aneuploidy in human embryos is about 10%, but this probability increases exponentially with the increase of female reproductive age, and even exceeds 50% in the late female reproductive age. Most embryonic aneuploidy is derived from the incorrect separation of female meiotic chromosomes. This is the first time the industry has proposed a "female perspective" on "chromosomal aneuploidy." It is understood that Zhang Liangran team and the team of Kleckner academicians have systematically analyzed and compared the meiotic recombination of male and female germ cells, elaborated the difference between the two sexes in meiosis recombination, and revealed that the embryo is not integrated. The root cause of the ploidy. The study found for the first time that chromosomal recombination is similar in most of the meiosis of amphoteric germ cells, but in women, about 25% of recombinant intermediates do not form true cross-recombination, resulting in “cross-mature defectsâ€. It is because of this female-specific "cross-mature defect" that causes high-frequency chromosome segregation errors, which ultimately leads to the generation of high-frequency aneuploid embryos. Source: Technology Daily Help Sleeping Plant Extract,Taraxacum Platycarpum Extract,Polygala Tenuifolia Extract,Gynostemma Pentaphyllum Extract Fufeng Sinuote Biotechnology Co.,Ltd. , https://www.sntextract.com