Cells are the basic unit of the structure and function of living organisms. All organisms (except viruses) are composed of cells. In-depth study of cells is the key to uncovering the mysteries of life and treating diseases. Cell culture technology has not made much progress in the past for a long time, and the development of microfluidic technology has brought tremendous opportunities for the study of cell biology. The channel size of the microfluidic chip matches the cell size, and the many advantages of the microfluidic chip make it an attractive platform for biological technology. Among them, the most critical aspect of microfluidic technology is the ability to regulate the microenvironment of cells in relative spatial and temporal scales. Traditional in vitro cell culture is difficult to meet experimental requirements In traditional in vitro cell culture, the cells are mostly adherent and two-dimensional. Since the cells after ex vivo lose the regulation of neurohumoral fluid and the interaction between cells, and in a relatively static environment, the cells are proliferated. It does not play its role as it does in the body, nor does it truly reflect its survival in the body. The microfluidic chip precisely controls cell microenvironmental factors such as substance concentration, solution temperature and pH; provides a tiny and complex structure to mimic the living environment of cells in the body. Microfluidic chip cell culture will become an important means Liver, lung cell and tissue culture can be performed on a microfluidic chip to construct an in vitro toxicological experimental model. In addition, microfluidic chips can also be used for the cultivation of stem cells and cancer cells. Because stem cells live under complex physical, chemical, and biological factors, traditional culture methods do not mimic their physiological environment and are subject to various limitations. Microfluidic chip technology can better simulate the complex life of stem cells in the body. The environment precisely controls various parameters in a high-throughput and variable manner. The biggest feature of cancer cells is invasion and metastasis. Microfluidic chips can simulate a series of processes in which cancer cells infiltrate into blood vessels, flow in blood vessels, ooze blood vessels and migrate to target tissues. It can be seen that the use of microfluidic chips to culture cells will become an important means of cell biology research. Organs-on-chips The Wyss Institute uses a technology that makes computer chips that implant live human organ cells onto a chip, while the chip mimics the environment in which cells are found in the human body. This chip is called organs-on-chips. It can be seen that the microfluidic chip can not only imitate the internal environment of cell growth, but also simulate the complete organs of the human body in the future, thereby reducing the dependence on animal test subjects and reducing the time and cost of developing drugs. Xi'an complex bio-tech CO.,LTD. , https://www.complexpowder.com
