How to choose the aperture of the liquid filter?

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In the production of lyophilized preparations, a method of removing microorganisms in a gas or a liquid used in a process by filtration using a principle that bacteria cannot pass through a dense pore filter medium is used. Mainly used for sterilization of heat-labile drug solutions or raw materials.

The prepared liquid needs to be filtered using a filter of appropriate pore size to remove the total impurities and bacteria from the liquid. The usual chemical filtration uses a filter of two or more different pore sizes in series to filter. In the actual production process, the filter is usually filtered by a filter with different pore sizes, and sometimes decarburization is required to remove the pyrogen. After the Zui, the liquid is filtered through a microporous filter with a pore size of 0.22 μm. When filtering the liquid, pay special attention to confirm the pore size of the sterilization filter and its integrity in the production process. That is, the filter membrane of the sterilization filter should be tested for bubble point and used after the test is passed.

Before the blending operation, the operator first checks the original auxiliary materials, name, batch number, and test report, checks the appearance quality, and then weighs the raw materials according to the prescription, and then performs the blending operation. The solution is sterile filtered before being filled, and after filtering, The filter is tested for integrity. When the liquid preparation system uses a method of filtering while filling, the system should use two sterilization filters in series to ensure that even if a filter membrane is damaged during the filtration and filling process, Does not affect the sterility of the filtrate.

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