Release date: 2013-06-21 Ifzx: No The use of electrical current to inject antigen into human immune cells has revolutionized asthma treatment. Source: Kexun Extremity Pack,Sterile Extremity Pack,Disposable Extremity Pack,Disposable Sterile Extremity Pack Xinxiang Huaxi Sanitary Materials Co., Ltd. , https://www.huaximedical.com
This hyperdynamic "vaccine" enables the immune system to overcome the stimulation of dust mite antigens, one of the emergency sources that cause asthma attacks.
Asthma attacks are triggered by the immune system's excessive reflection of dust mites releasing large amounts of histamine. The rapid release of histamine causes swelling and irritation of the airways leading to dyspnea and asthma attacks.
The current "vaccine" for the treatment of asthma is immunotherapy, which is achieved by multiple injections of small doses of harmful dust mite protein. This is done to allow the immune system to gradually adapt to dust mites and avoid overreaction. This method is capable of stimulating the production of protective cells that inhibit excessive responses. However, treatment takes a long time and usually takes 50 to 80 injections over a period of five years.
Scientists have invented a new vaccine that replaces real dust mite proteins with traces of dust mite protein DNA. In the new technology, DNA is infused into the body and absorbed by immune cells, and the DNA can be used to produce dust mites. This microscopic exposure allows the immune system to gradually adapt to the stimulation of protein antigens to produce protective cells. This method requires only one injection.
However, many cells have a protective film that acts as a serosa layer. Previous vaccines required this protective film. This electrically driven vaccine overcomes this problem. At Chulalongkorn University in Bangkok, Thailand, scientists used electrical impulses to inject DNA vaccines containing dust mite antigens into mice through the skin. This pulse can briefly break through the protective outer membrane of immune cells. The number of protective cells produced by this electrical pulse injection is forty times that of a conventional vaccine.
The research team is conducting experiments to ensure that this method works for humans. Malayka Rahman of the British Asthma Research Center said: "Most asthma patients say that dust stimulates their symptoms and increases their risk of asthma attacks. However, dust exposure is difficult to avoid. Even though researchers have taken an important step toward researching effective vaccines, But this is still in its early stages."