The Hong Kong University of Science and Technology said on the 18th that the research team of the school and the Chinese Academy of Sciences and Jinan University recently discovered a new mechanism that can delay the damage of damaged nerves, bringing about the treatment of nerve damage and neurodegenerative diseases such as Parkinson's disease. new Hope.

Liu Kai, associate professor of the Department of Life Science of the Department of Life Sciences of the Hong Kong University of Science and Technology, Professor Fang Yanwei of the Center for Biological and Chemical Interdisciplinary Research at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, and Professor Li Ang from the Guangdong, Hong Kong and Macao Central Nervous Regeneration Institute of Jinan University, discovered a brand new Protein Vps4 that delays the degradation of damaged nerves.

According to the team, axons are elongated protrusions that extend from neurons and nerve cells and are responsible for transmitting messages to muscles and other nerve cells. Once axons are not maintained intact, axonal death and neurodegeneration can result.

Through genetic screening of Drosophila and subsequent verification in mice, the team found that up-regulation of Vps4 expression can effectively delay the damage of damaged nerves in in vitro cell experiments or in vivo experiments in mice. day.

In addition, Vps4 has an autophagy function, a mechanism that counteracts the negative effects of damage and aging on neurodegeneration by removing damaged proteins and organelles. Therefore, the absence of Vps4 will trigger autophagic dysfunction and lead to future axonal degeneration.

Liu Kai said that the experimental results show that 70% of axons do not see significant degradation in 3 days. This new discovery is a major breakthrough in understanding the regulation of axonal integrity and the molecular mechanism of neurodegeneration. He said that after inhibition of injury, rapid degradation of Vps4 in axons is an important direction for future research, and the team hopes to explore stronger neuroprotective efficacy.

This research project benefited from the policy of mainland research funding that was introduced last year to transit Hong Kong. Research results have been published in the scientific journal Science Advances. (According to Xinhua News Agency reporter Zhang Yashi)

Source: Health News Network

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