I. Status of disinfection application of vaporized hydrogen peroxide (VHP) solution

Vaporized hydrogen peroxide (H 2 O 2 ) is a naturally occurring chemical widely found in air and water. As early as the eighteenth century, humans discovered and began to use hydrogen peroxide, and it is widely used in food, beverage, medical equipment and health care. The use of vaporized hydrogen peroxide is mainly dependent on its oxidizing properties, and different concentrations of vaporized hydrogen peroxide have different uses. Generally, medical vaporized hydrogen peroxide (commonly known as hydrogen peroxide) is used at a concentration of 3%, and is mainly used for disinfection of wounds or otitis media. When it meets the wounds, pus or dirt of the skin, mouth and mucous membranes, it immediately decomposes to form oxygen. This oxygen atom, which has not been combined into oxygen molecules, has a strong oxidizing power and can destroy bacteria when it comes into contact with bacteria. Bacteria, kill bacteria. The remaining material after killing the bacteria is water and oxygen without any poison and without any stimulating effect. There is no secondary pollution and resistance. Therefore, medical hydrogen peroxide is the ideal disinfectant for wound disinfection. The concentration of vaporized hydrogen peroxide for industrial use is generally 25-50%. The high concentration of vaporized hydrogen peroxide is highly corrosive and has the risk of explosion. The concentration of more than 8% requires special containers for packaging and transportation. Liquid vaporized hydrogen peroxide is used for disinfection requiring high concentrations and long contact times to kill highly resistant microorganisms, such as bacterial spores and molds, such as the FDA approved 7.5% vaporized hydrogen peroxide disinfectant from Reckitt & Colman Inc. When the surface is sterilized at a high level, the soaking time of 20 ° C is required to be 6 hrs.

Second, the status quo of vaporization hydrogen peroxide space sterilization technology

In the 1980s, researchers in the United States first discovered that the ability of gaseous vaporized hydrogen peroxide to kill bacteria was more than 200 times greater than that of liquid vaporized hydrogen peroxide. That is, vaporized hydrogen peroxide can achieve the sporicidal ability of high-concentration liquid vaporized hydrogen peroxide in a gas phase state, and thus two different sterilization and sterilization technologies utilizing vaporized hydrogen peroxide gas are present. Gasification vaporization hydrogen peroxide sterilization technology and vaporization hydrogen peroxide "dry fog" sterilization and sterilization technology.

(1) Vaporization hydrogen peroxide sterilization technology

Most of the vaporization hydrogen peroxide sterilization technology uses a flashing technique to drop a high concentration of vaporized hydrogen peroxide solution (concentration generally greater than 30%) onto the surface of a heated smooth metal object to instantly vaporize it to 2-6 microns. particle. At present, it is mainly divided into two camps, namely the VSP (Vaporized Hydrogen Peroxide) sterilization technology of American Steris and the wet HPV (Hydrogen Peroxide Vapour) sterilization technology of Bioquell. At present, the vaporization and vaporization hydrogen peroxide sterilization method has become the recommended method for the pharmacopoeia, GMP, disinfection and sterilization technical specifications of various countries. The sterilization process is very mature and reproducible. There are special chemical indicators and biological indicators to verify vaporization. The distribution of hydrogen peroxide gas is uniform and the level of sterility is guaranteed. Can be widely used in many fields such as biopharmaceutical factories, medical and health, biological laboratories and animal research laboratories.

(2) Vaporized hydrogen peroxide "dry fog" disinfection and sterilization technology

Since the vaporized hydrogen peroxide sterilization equipment developed by the flash technology requires high concentration of vaporized hydrogen peroxide, it is highly corrosive and the equipment is expensive, and its use range is limited to small corrosion-resistant and confinable spaces such as transfer chambers and isolation. Disinfection and sterilization of sterilizers, freezers, biological safety cabinets, medical equipment, biological incubators and airlocks are not suitable for disinfection and sterilization of large spaces such as GMP clean workshops and hospital operating rooms.

With the development of atomization technology, it has been possible to atomize the disinfectant into small particles of less than 10 μm, the so-called dry mist technology. Since the small particles perform irregular motion in the air (the Brownian motion principle) and do not settle, they do not aggregate together to produce large droplets, which rebound after contact with the surface of the object without breaking. The surface is moist. Therefore, these properties of dry fog make it very diffuse, leaving no dead ends when disinfecting; not wetting the surface; not corroding equipment, color steel plates and walls. Studies have shown that the smaller the atomized particles, the longer the suspension time in the air, the more chance there is to have sufficient contact with the bacteria in the air to achieve the purpose of sterilization. The main products are the Phileas vaporized hydrogen peroxide dry fog space sterilization equipment from France DEVEA and the Nocospray dry mist equipment from Oxy'Pharm. Phileas Vaporized Hydrogen Peroxide Dry Mist Space Sterilization Equipment utilizes the uniquely designed principle of a fast-rotating valve flap diffusely reflecting liquid. The vaporized hydrogen peroxide is evenly sprayed and the droplets can be controlled at 5-10 μm. The atomized vaporized hydrogen peroxide undergoes random Brownian motion throughout the enclosed space, adhering to the surface of the microorganism, destroying its cell wall, thereby achieving complete sterilization. The technology works without the use of any vents or compressed air, and the resulting mist quickly diverge, forming a dry mist of sterilized vaporized hydrogen peroxide in the operating space without damaging the surface of the contact. The main equipment models are Phileas100 and Phileas 500.

Zibo Weishi Medical Technology Co., Ltd. main products are: VHP sterilizer, hydrogen peroxide sterilizer, glove integrity tester, online glove leak detector, formaldehyde fumigation sterilizer, Forma Lin sterilizer and so on.

Portable Ultrasound Series

SS-8 ARM Laptop Ultrasound B Scanner