Cell therapy or treatment of asthma March 29, 2017 Source: Bio Valley The incidence of asthma is rising, especially in developed countries. One of the reasons is the rising health conditions. Epidemiological studies have shown that exposure to allergic reactions, especially asthma, is relatively important in a relatively "unsanitary" microbial environment. Conversely, excessive hygiene will increase the risk of asthma in children. During the onset of asthma, the body's immune system produces an abnormal immune response to antigens in some common environments. In a recent article published in the journal Immunology, researchers from the University of Liège have shown that DNA exposed to bacteria promotes the proliferation of macrophages in the lungs, regulating the immune response in the lungs and alleviating asthma. occur. This finding provides a new idea for the treatment of asthma patients by alleviating allergic reactions by transplanting lung regulatory macrophages. The study was led by Prof. Fabrice Bureau and Professor Thomas Marichal from Liège University. Although there have been a large number of articles on the human and mouse level to prove that bacterial DNA analogs can effectively treat asthma, these drugs are not currently licensed to enter the market. This may be due to its potential toxicity and intrinsic mechanism of action. However, this study further explains the molecular mechanisms involved, and perhaps this research can help the establishment of new related therapies. In this trial, the researchers first looked at whether exposure to microbial molecules (including microbial cell wall components, or DNA, etc.) would affect the environment of the lungs. They found that bacterial DNA specifically induces the production of regulatory macrophages in the lungs, and this effect can last for several months. Interestingly, if these macrophages were collected and transplanted into asthmatic mice that were not stimulated by microbial DNA, it was found that the treatment could equally alleviate asthma symptoms in mice. Based on the above results, the researchers hope to find cell types with similar characteristics from the human body, and this finding may be applied to the clinical treatment of asthma patients. Our hi vis jackets come in a broad range of styles including soft shell, windbreaker, bomber jacket, parka, reversible, packable pullover, 3-season, and body warmer. These ANSI Class 2, ANSI Class 3 or Non-ANSI compliant jackets include high visibility Lime and Orange with a variety or reflective tapes for differing work environments. Silver reflective tape is a top choice for price based performance. The high contrast tape/stripe offers increased daytime visibility. Prismatic reflective tapes offer superior brightness and performance in wet weather conditions. Stay warm, dry, comfortable and safe on the job with a high visibility ANSI safety jacket. High Visibility Jacket,High Visibility Coats & Jackets,Safety Reflective Jacket,Leather Welding Jacket Ningbo Staneex Imp. & Exp. Co., Ltd. , https://www.staneex.com