Release date: 2016-02-29 After a three-year effort, the team of the Hunan Provincial Key Laboratory of Dermatology and Epidemiology of the Second Xiangya Hospital of Central South University, Professor Lu Qiang, developed a new diagnostic marker with high specificity and sensitivity for systemic lupus erythematosus. For the first time in the world, the diagnosis of the disease has been raised to the genetic level. Related research papers were recently published in the internationally renowned medical journal "Rheumatology Yearbook". Source: Health News Nuts are a group of cleistoses that have a hard skin and contain a single seed. It is the essence of plants, rich in nutrition, containing higher minerals, vitamins, oil and protein, eating more can promote growth and development, increase physical fitness. Common nuts include walnuts, peanuts, almonds, cashews, macadamia nuts, pistachio nuts and so on. Nuts, Almonds,Walnuts,Pistachio nuts,Macadamia nuts Xi'an Gawen Biotechnology Co., Ltd , https://www.seoagolyn.com
Systemic lupus erythematosus is an autoimmune disease that occurs in women during childbirth. It often affects vital organs such as skin, blood, kidneys, joints and brain, causing great harm to patients' health and even life-threatening. At present, the number of patients with systemic lupus erythematosus in China exceeds 1 million. Although a large number of studies have been carried out by scientists in various countries, there is still a lack of high-specificity and high-sensitivity diagnostic markers in clinical practice, which leads to the lack of accurate diagnosis of some patients with systemic lupus erythematosus.
Over the past three years, with the support of the National Natural Science Foundation of China and major international collaborative research projects, the Lu Qiang team first used DNA methylation chips to screen for differential methylation sites in peripheral blood DNA of patients with systemic lupus erythematosus. At the Second Xiangya Hospital of Central South University, 337 patients with systemic lupus erythematosus, 353 patients with rheumatoid arthritis and 358 normal subjects were tested for DNA samples. The methylation level of IFI44L gene was screened as systemic erythema. A marker for the diagnosis of lupus and further validated the specificity and sensitivity of the marker. Subsequently, Professor Amr H. Sawalha of the University of Michigan in the United States conducted a validation in the European systemic lupus erythematosus population.
Lu Qianjin introduced that the IFI44L gene methylation level can distinguish between patients with systemic lupus erythematosus and normal people and other autoimmune diseases, significantly improving the reliability and accuracy of systemic lupus erythematosus diagnosis, but also Can be applied to the judgment of the efficacy of systemic lupus erythematosus. It is of great significance to improve the clinical diagnosis and treatment level for the precise medical treatment of systemic lupus erythematosus, and has broad clinical application prospects.