Release date: 2009-03-13 A recent article published in the Journal of Rheumatology reported that in the early stages of rheumatoid arthritis (RA), the presence of inflammation affects the hypothalamic-pituitary-gonadal axis, mainly sex hormone levels, rather than the hypothalamus. - Pituitary level. The study was conducted by Swedish researchers in 41 patients with early RA who had less than 1 year of joint symptoms, with an average age of 53 years and an average disease duration of 6 months. The researchers followed up for 2 years and analyzed disease activity (DAS28), functional impairment (health assessment questionnaire), serum total testosterone levels, non-sex hormone binding protein-bound testosterone, luteinizing hormone (LH) At the same time, 131 healthy people entered the study as a control. The results showed that the average testosterone level of patients was lower than that of normal people, and the level of LH was significantly lower in patients older than 50 years, accompanied by mild gonadotropin-type hypogonadism. The mean testosterone level increased significantly in patients with good therapeutic effects, and the decrease in DAS28 score was associated with elevated testosterone levels. LH levels remained low and were not associated with disease activity. Meditech Medical Network
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